Combined treatment in carcinoma of the nasopharynx
From October 1982 to August 1984, 30 previously untreated patients with biopsy-proven carcinoma of the nasopharynx, stage III (26.5%) and stage IV (73.5%), received combined radiotherapy (6,000 to 7,000 cGy over a period of 7 to 7.5 weeks) and chemotherapy (mitomycin-C 10 mg/M2, IV; 5-fluorouracil 750 mg/M2, IV; and methotrexate 30 mg/M2, IV) concomitantly. There were 20 males and 10 females, with a median age of 40 years. Minimal follow-up duration was 24 months. Actuarial overall survival rate at 48 months was 49%. Complete local response was achieved in 75% of the patients, with 31% of the cases failing distantly. The complication rate was high and included severe mucositis, xerostomia, and septicemia (fatal in two cases). Despite high local disease control, survival rate did not increase. A randomized trial is urgently needed to establish whether or not combined treatment is of value in advanced carcinoma of the nasopharynx.
- Research Organization:
- McGill Univ., Montreal, Quebec (Canada)
- OSTI ID:
- 6923865
- Journal Information:
- Laryngoscope; (United States), Vol. 98:8
- Country of Publication:
- United States
- Language:
- English
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COMBINED THERAPY
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ANTIBIOTICS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
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550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine