Exercise and caloric restriction modify rat mammary carcinogenesis
This study was designed to determine the effect of energy expenditure and dietary restriction on tumorigenesis. Energy balance was altered in a 2 x 2 factorial experiment by: 1) exercising rats by running on a treadmill or 2) a 16% reduction in caloric intake. Treatments were begun 24 days after initiation and continued for 160 days. Mammary cancer was initiated with 10 mg of 7,12-dimethylbenzanthracene given intragastrically. All 4 groups received the same quantity of fat, protein vitamins, minerals and sucrose in the diet. Energy restriction (ER) was achieved by removing 15% of the corn starch from the diet fed to the ER groups. Energy content of the carcass (as a % of the ad lib., sedentary group) was: pair-fed, EX = 71; ER, sedentary = 75; ER, EX = 61. ER decreased total body protein by 6%. EX did not change body protein. EX reduced the rate constant (rate constant is the change in tumor incidence or size with time) of the cummulative mean tumor incidence by 16% and ER reduced the rate constant by 28%. EX decreased the rate constant of the cummulative mean tumor size by 23%; however, ER increased the rate constant by 46%. In this experiment, EX was equally or more effective than ER in reducing tumorigenesis.
- Research Organization:
- Michigan State Univ., East Lansing
- OSTI ID:
- 6914049
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DIMETHYLBENZANTHRACENE
CARCINOGENESIS
EXERCISE
BIOLOGICAL EFFECTS
MAMMARY GLANDS
NEOPLASMS
DIET
RATS
TOXICITY
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
DISEASES
GLANDS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology