Effect of high fat, fiber and caloric restriction on rat mammary tumorigenesis
Female rats given 7,12-Dimethylbenz(a)anthracene (DMBA) were placed on diets of control fat (CF-4.5%) or high fat (HF-20%) with either control fiber (6%) or high fiber (FB-12%). A 60% reduction in the CF diet was used to study the effects of caloric restriction on tumorigenesis. Results showed that HF diets had a shorter latency period than CF rats. The respective average number of tumors per rat and tumor volume were 7.3 +/- 1.3 and 23694 mm/sup 2/ for rats on a HF diet and 5.1+/-1.1 and 9144 mm/sup 3/ for CF rats. Addition of high fiber to the diets reduced the tumor incidence from 95% to 70% in the CF group but did not reduce the incidence in HF group. Although tumor number was reduced to 3.7+/-1.5 in CF+FB rats, the tumor volumes were not reduced (8950 mm/sup 3/). Rats fed HF+FB did not have fewer tumors (7.0+/-1.1), but did show a 53% reduction in tumor load. The estrogen dependent enzyme glucose-6-phosphate dehydrogenase was not affected by dietary levels of fat, which suggests that the promotional effects of fat may not be through estrogen stimulation. None of the caloric restricted rats had tumors 12 weeks post-DMBA. These restricted rats all had significantly elevated levels of serum corticosterone.
- Research Organization:
- Morehead State Univ., KY
- OSTI ID:
- 7132261
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DIMETHYLBENZANTHRACENE
CARCINOGENESIS
FATS
BIOLOGICAL EFFECTS
FIBERS
MAMMARY GLANDS
NEOPLASMS
CORTICOSTERONE
DIET
OXIDOREDUCTASES
RATS
ADRENAL HORMONES
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
CORTICOSTEROIDS
DISEASES
ENZYMES
GLANDS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PREGNANES
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology