Efficiency of energy utilization: effects of diet composition on body composition and mammary neoplasia

Conference · Wed Mar 05 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:6956233

Boissonneault, G A; Elson, C E; Pariza, M W

Multiple interactions between the efficiency of utilization of dietary fat and carbohydrate energy, energy intake changes in body composition and 7,12-dimethylbenz(a)anthracene (DMBA) DMBA-induced mammary tumorigenesis were examined using female F-344 rats. The rats were fed ad libitum a semipurified diet containing 5% corn oil (LF) from weaning to 50 d of age at which each was given, by gavage, 65 mg DMBA/kg body weight. The rats were randomly assigned to diets containing 5% 17.5% (MF) and 30% (HF) corn oil. All diets were balanced with respect per unit of energy in terms of protein, vitamins, minerals and fiber. For 28 d post-DMBA, the rats were fed 40 or 42 kcal daily and thereafter, diet was provided ad libitium. Daily energy intakes were recorded throughout the study. The mean energy intakes during the first 35 wk were: LF, 240 +/- 12.3 kcal/wk; MF, 237 +/- 11.7 kcal/wk; and HF, 237 +/- 11.1 kcal/wk. Body weight at 35 wk were: LF, 196 +/- 9.5 g; MF, 206 +/- 13.9 g; and HF, 210 +/- 20.6 g. No differences in tumor incidence (LF, 55%; MF, 46%; HF, 51%), tumors/group (LF, 24; MF, 28; HF, 25) and tumors/tumor-bearing rat (LF, 1.3 +/- 0.7; MF 1.6 +/- 1.0;p HF, 1.2 +/- 0.4) were noted. Within dietary groups tumor incidence was positively correlated with energy intake. However, there were no differences among the various parameters between dietary groups at any energy intake level. Body compositions were monitored during this study. The body fat mass and % carcass weight increased in parallel with the % dietary fat. Concomitantly, % lean body and, to a lesser extent lean body mass decreased. Both body size and body composition, influenced by energy intake and retention, affected the response to DMBA.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 6956233
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZANTHRACENE
BODY
BODY COMPOSITION
CARBOHYDRATES
CARCINOGENESIS
CONDENSED AROMATICS
DIET
EXPERIMENTAL NEOPLASMS
FATS
GLANDS
HYDROCARBONS
MAMMALS
MAMMARY GLANDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
VERTEBRATES