Effect of dietary fat on x-ray-induced mammary cancer in Sprague-Dawley rats
Journal Article
·
· J. Natl. Cancer Inst.; (United States)
OSTI ID:6880241
- Naylor Dana Inst. for Disease Prevention, Valhalla, NY
We studied the effect of dietary fat levels on the induction of mammary cancer by 350 rads total-body x-radiation given to noninbred albino Sprague-Dawley rats at 50 days of age. Compared to rats on a low-fat (LF) diet (5% lard), rats on a high-fat (HF) diet (20% lard) from 30 days of age had more tumors, with a higher multiplicity of carcinomas per rat. LF-fed groups exhibited a longer median tumor latency period than did HF-fed groups. A similar trend toward more tumors with an earlier time of death was seen in rats given single iv doses of 50 mg 1-methyl-1-nitrosourea/kg and fed an HF diet as compared to an LF diet.
- OSTI ID:
- 6880241
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 64:3; ISSN JNCIA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DELAYED RADIATION EFFECTS
DIET
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FATS
GLANDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
IONIZING RADIATIONS
IRRADIATION
LATENCY PERIOD
MAMMALS
MAMMARY GLANDS
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SIDE EFFECTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DELAYED RADIATION EFFECTS
DIET
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FATS
GLANDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
IONIZING RADIATIONS
IRRADIATION
LATENCY PERIOD
MAMMALS
MAMMARY GLANDS
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SIDE EFFECTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION