Importance of dietary fat during initiation versus promotion in rat mammary cancer
This study was designed to determine if the fat content of the diet would alter 7,12-dimethylbenzanthracene (DMBA) initiation of mammary carcinogenesis. Female Sprague-Dawley rats were fed the AIN-76 (high carbohydrate, HC) diet or a modified AIN-76 diet (high fat (37/sup 5/), HF) prior to initiation. The HF diet had the same energy to nutrient ratio as the HC diet. Two groups were fed either the HC or the HF diet during the initiation and promotion phase (HC-HC and HF-HF groups). A third group was fed the HF diet 20 days before and 12 days after initiation and then were fed the HC diet during the promotion phase (HF-HC group). Weight gain during promotion was similar for the HC-HC and HF-HC groups, but the HF-HF group gained 41% more weight. The HC-HC group had significantly fewer tumors than the HF-HF or HF-HC groups (HC-HC = 1.45 tumors/rat; HF-HF = 2.75 and HF-HC = 3.63). Surprisingly, feeding the HC diet during promotion did not cause a decrease in tumorigenesis (there was actually a non-significant increase). This work demonstrates that the fat (energy) content of the diet during DMBA initiation is critical. Furthermore, the fat (energy) content of the diet during initiation was more critical than during promotion.
- Research Organization:
- Michigan State Univ., East Lansing
- OSTI ID:
- 6962249
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DIMETHYLBENZANTHRACENE
CARCINOGENESIS
FATS
BIOLOGICAL EFFECTS
MAMMARY GLANDS
NEOPLASMS
CARBOHYDRATES
DIET
RATS
TOXICITY
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
DISEASES
GLANDS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology