Second cancers following radiotherapy for cervical cancer
Incidence of second primary cancers was evaluated in 7,127 women with invasive cancer of the cervix uteri, diagnosed between 1935 and 1978, and followed up to 38 years (average, 8.9 yr) in Connecticut. Among 5,997 women treated with radiation, 449 developed second primary cancers compared with 313 expected (relative risk . 1.4) on the basis of rates from the Connecticut Tumor Registry. Excess incidence was noticeable 15 years or more after radiotherapy and attributed mostly to cancers of sites in or near the radiation field, especially the bladder, kidneys, rectum, corpus uteri, and ovaries. No excess was found for these sites among the 1,130 nonirradiated women. The ratio of observed to expected cancers for these sites did not vary appreciably by age at irradiation. The data suggested that high-dose pelvic irradiation was associated with increase in cancers of the bladder, kidneys, rectum, ovaries, corpus uteri, and non-Hodgkin's lymphoma but, apparently, not leukemia, Hodgkin's disease, breast cancer, or colon cancer.
- Research Organization:
- Environmental Epidemiology Branch, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD
- OSTI ID:
- 6794568
- Journal Information:
- JNCI, J. Natl. Cancer Inst.; (United States), Vol. 69:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Second cancers following radiation treatment for cervical cancer. An international collaboration among cancer registries
Radiation dose and second cancer risk in patients treated for cancer of the cervix
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
UROGENITAL SYSTEM DISEASES
AGE DEPENDENCE
BIOLOGICAL RADIATION EFFECTS
BLADDER
KIDNEYS
LOCAL IRRADIATION
OVARIES
PATIENTS
RADIATION DOSES
RECTUM
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
DOSES
FEMALE GENITALS
GASTROINTESTINAL TRACT
GONADS
INTESTINES
IRRADIATION
LARGE INTESTINE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
URINARY TRACT
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man