Second cancers following radiation treatment for cervical cancer. An international collaboration among cancer registries
The numbers of second cancers among 182,040 women treated for cervical cancer that were reported to 15 cancer registries in 8 countries were compared to the numbers expected had the same risk prevailed as in the general population. A small 9% excess of second cancers (5,146 observed vs. 4,736 expected) occurred 1 or more years after treatment. Large radiation doses experienced by 82,616 women did not dramatically alter their risk of developing a second cancer; at most, about 162 of 3,324 second cancers (approximately equal to 5%) could be attributed to radiation. The relative risk (RR = 1.1) for developing cancer in organs close to the cervix that had received high radiation exposures--most notably, the bladder, rectum, uterine corpus, ovary, small intestine, bone, and connective tissue--and for developing multiple myeloma increased with time since treatment. No similar increase was seen for 99,424 women not treated with radiation. Only a slight excess of acute and non-lymphocytic leukemia was found among irradiated women (RR = 1.3), and substantially fewer cases were observed than expected on the basis of current radiation risk estimates. The small risk of leukemia may be associated with low doses of radiation absorbed by the bone marrow outside the pelvis, inasmuch as the marrow in the pelvis may have been destroyed or rendered inactive by very large radiotherapy exposures. There was little evidence of a radiation effect for cancers of the stomach, colon, liver, and gallbladder, for melanoma and other skin cancers, or for chronic lymphocytic leukemia despite substantial exposures.
- OSTI ID:
- 5012233
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
LEUKEMIA
RADIOINDUCTION
NEOPLASMS
RADIOTHERAPY
SIDE EFFECTS
BLADDER
BONE MARROW
DELAYED RADIATION EFFECTS
EPIDEMIOLOGY
FEMALE GENITALS
INTERNATIONAL COOPERATION
LARGE INTESTINE
LIVER
RADIATION DOSES
RECTUM
RISK ASSESSMENT
SKELETON
SMALL INTESTINE
STATISTICS
STOMACH
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COOPERATION
DIGESTIVE SYSTEM
DISEASES
DOSES
GASTROINTESTINAL TRACT
GLANDS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INTESTINES
MATHEMATICS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
TISSUES
URINARY TRACT
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)