Absorption, distribution, and excretion of /sup 14/C-trihalomethanes in mice and rats

Journal Article · Sat Nov 01 00:00:00 EST 1986 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01607835· OSTI ID:6787755

Mink, F L; Brown, T J; Rickabaugh, J

Chloroform and other trihalomethanes have been shown to originate from reactions between chlorine and naturally-occurring organic precursors in water. Chloroform (TCM) has been shown, at high dose levels, to increase the tumor incidence in mice and rats. Studies by lardiff demonstrated chloroform was not mutagenic in the Ames bioassay using Salmonella typhimurium strains TA100 and TA1535. Bromodichloromethane, dibromochloromethane and bromoform demonstrated a dose-related mutagenic response. Differences in biological responses between mice and rats have been attributed to differences in their relative rates of TCM metabolism. Several predictive studies estimate that the mouse metabolizes TCM at a significantly different rate than the rat. This study was initiated to determine the absorption, distribution and excretion characteristics of four trihalomethanes (TCM, TBM, DBCM and BDCM) using the carbon 14 labeled compounds under identical experimental conditions in both the mouse and rat.

• Research Organization: Environmental Protection Agency, Cincinnati, OH
• OSTI ID: 6787755
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 37:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBON 14 COMPOUNDS
EXCRETION
INTESTINAL ABSORPTION
TISSUE DISTRIBUTION
HALOGENATED ALIPHATIC HYDROCARBONS
BROMOFORM
CHLOROFORM
DOSE-RESPONSE RELATIONSHIPS
MICE
ORAL ADMINISTRATION
RATS
ABSORPTION
ANIMALS
BROMINATED ALIPHATIC HYDROCARBONS
CHLORINATED ALIPHATIC HYDROCARBONS
CLEARANCE
DISTRIBUTION
LABELLED COMPOUNDS
MAMMALS
ORGANIC BROMINE COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RODENTS
UPTAKE
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550601 - Medicine- Unsealed Radionuclides in Diagnostics