Effects of pre- and postoperative irradiation on the healing of bone grafts in the rabbit

Journal Article · Thu Jan 01 00:00:00 EST 1987 · J. Oral Maxillofac. Surg.; (United States)

DOI:https://doi.org/10.1016/0278-2391(87)90083-8· OSTI ID:6776137

Morales, M J; Marx, R E; Gottlieb, C F

Healing of cellular bone grafts irradiated at various times in the postsurgical course was compared to the healing characteristics of bone grafts placed into already irradiated tissue and to controls of irradiated host mandible in a rabbit model. Physical graft consolidation was assessed by load stress characteristics and serial histologic examination. Results indicated that grafts placed into already irradiated tissues failed to form bone in both phases of expected regeneration resulting in structurally weakened and histologically deficient ossicles. Bone grafts irradiated after placement were tolerant of irradiation. Bone grafts irradiated after four weeks were found to be less affected by irradiation than those irradiated within the first four weeks, forming an ossicle structurally and histologically superior to that of bone ossicles developed from grafts placed into irradiated tissues.

• Research Organization: Univ. of Miami School of Medicine, FL
• OSTI ID: 6776137
• Journal Information: J. Oral Maxillofac. Surg.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SKELETON
GRAFTS
WOUNDS
HEALING
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL REGENERATION
GRAFT-HOST REACTION
IRRADIATION
JAW
RABBITS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
INJURIES
MAMMALS
ORGANS
RADIATION EFFECTS
RECOVERY
SKULL
TRANSPLANTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals