Definition of hepatic tumor microcirculation by Single Photon Emission Computerized Tomography (SPECT)

Journal Article · Sat Sep 01 00:00:00 EDT 1984 · J. Nucl. Med.; (United States)

OSTI ID:6757022

Gyves, J W; Ziessman, H A; Ensminger, W D; Thrall, J H; Niederhuber, J E; Keyes, Jr, J W; Walker, S

Single photon emission computerized tomography coupled with Tc-99m MAA hepatic-arterial perfusion scintigraphy has been used to examine the density of the functional microcirculation of hepatic tumors relative to normal liver in 24 patients. In both colorectal and carcinoid tumors the authors have demonstrated an average three-fold greater arteriolar-capillary density in areas of tumor proliferation. The depth of the evoked tumor hypervascularity was found to extend about 4 cm. Tumors greater than 8-9 cm in diameter were uniformly found to have a central hypovascular core. These observations are of importance in the design of selective strategies utilizing therapeutic microspheres directed against the hypervascular proliferating regions of human tumors.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor
• OSTI ID: 6757022
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:9
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LIVER
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
NEOPLASMS
BLOOD CIRCULATION
TECHNETIUM 99
ALBUMINS
CELL PROLIFERATION
ISOMERIC NUCLEI
RADIOCOLLOIDS
SULFUR COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COLLOIDS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
EMISSION COMPUTED TOMOGRAPHY
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics