Regional blood flow in the domestic fowl immediately following chronic acceleration
In order to examine the effects of chronic low G acceleration on blood flow distribution and cardiac output, chickens (N.10) were centrifuged at +2Gz for 30-61 d. Controls (N.12) were not centrifuged. The animals were anesthetized with sodium pentobarbital after removal from the centrifuge and surgically prepared in order to measure cardiac output and regional blood flows by the reference sample method with /sup 85/Sr labeled microspheres (15 +/- 5 mum diam.). Both brachial arteries were cannulated to withdraw timed, paired blood samples at a known rate. The chest was opened and a cannula inserted into the left ventricle for administration of microspheres. Tissue samples were taken after completion of experimental procedures and their radioactivity was determined. The cardiac outputs in the two groups were not significantly different. Regional blood flows to the kidney, eyes, and skeletal muscle were significantly increased in the animals subjected to chronic +2Gz. While the mechanism by which these increases in blood flow occurred is not known, results indicate that chronic exposure to hyperdynamic gravitational fields can alter circulatory dynamics. We conclude that the cardiovascular system is directly involved in the process of adaptation to chronic positive acceleration.
- Research Organization:
- Department of Animal Physiology, University of California, Davis, CA
- OSTI ID:
- 6642453
- Journal Information:
- Aviat., Space Environ. Med.; (United States), Vol. 53:7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ACCELERATION
BIOLOGICAL EFFECTS
CHICKENS
SENSITIVITY
STRONTIUM 85
DIAGNOSTIC USES
BLOOD CIRCULATION
BLOOD FLOW
LABELLED COMPOUNDS
MICROSPHERES
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BIRDS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FOWL
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
RADIOISOTOPES
STRONTIUM ISOTOPES
USES
VERTEBRATES
560400* - Other Environmental Pollutant Effects
551001 - Physiological Systems- Tracer Techniques