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Regional blood flows by the microsphere method: reproducibility in portal hypertensive rats and influence of a portal vein catheter

Journal Article · · Proc. Soc. Exp. Biol. Med.; (United States)
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To determine the reproducibility of splanchnic blood flow measurements by the microsphere method in rats with portal hypertension and the effects of laparotomy with portal vein cannulation, eight groups of 10 rats were studied. Microspheres were labelled with /sup 113/Sn or /sup 141/Ce. Laparotomy with portal cannulation had no significant effect in sham-operated rats. In awake portal hypertensive rats, cardiac output and splanchnic blood flow were lower in portal vein cannulated rats compared with those of non-cannulated animals. In anesthetized portal hypertensive rats blood flows were unaffected by portal cannulation, but arterial pressure and heart rate were elevated. Anesthesia also decreased portal pressure in portal hypertensive rats. We conclude that the microsphere method remains reproducible in portal hypertensive rat models. Laparotomy with portal cannulation can alter systemic and splanchnic hemodynamics in portal hypertensive rats; these effects can also be changed during pentobarbital anesthesia. Regional blood flow measurements in portal hypertensive rats should be performed in animals without portal cannulation and preferably in the awake state.

Research Organization:
Institut National de la Sante et de la Recherche Medicale, Clichy (France)
OSTI ID:
6902332
Journal Information:
Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 187:4; ISSN PSEBA
Country of Publication:
United States
Language:
English

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Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
CARDIOVASCULAR DISEASES
CERIUM 141
CERIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HYPERTENSION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
MAMMALS
MEASURING METHODS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
NUCLEI
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RODENTS
SYMPTOMS
TIN 113
TIN ISOTOPES
VASCULAR DISEASES
VERTEBRATES