A genetic linkage map of the chromosome 4 short arm
- Massachusetts General Hospital, Boston (United States)
- Columbia Univ., New York, NY (United States)
- Indiana Univ. Medical Center, Indianapolis (United States)
- Columbia Univ., New York, NY (United States) Hereditary Disease Foundation, Santa Monica, CA (United States)
- Massachusetts General Hospital, Boston (United States) Harvard Univ., Boston, MA (United States)
The authors have generated an 18-interval contiguous genetic linkage map of human chromosome 4 spanning the entire short arm and proximal long arm. Fifty-seven polymorphisms, representing 42 loci, were analyzed in the Venezuelan reference pedigree. The markers included seven genes (ADRA2C, ALB, GABRB1, GC, HOX7, IDUA, QDPR), one pseudogene (RAF1P1), and 34 anonymous DNA loci. Four loci were represented by microsatellite polymorphisms and one (GC) was expressed as a protein polymorphism. The remainder were genotyped based on restriction fragment length polymorphism. The sex-averaged map covered 123 cM. Significant differences in sex-specific rates of recombination were observed only in the pericentromeric and proximal long arm regions, but these contributed to different overall map lengths of 115 cM in males and 138 cM in females. This map provides 19 reference points along chromosome 4 that will be particularly useful in anchoring and seeding physical mapping studies and in aiding in disease studies. 26 refs., 1 fig., 1 tab.
- OSTI ID:
- 6596770
- Journal Information:
- Somatic Cell and Molecular Genetics; (United States), Vol. 19:1; ISSN 0740-7750
- Country of Publication:
- United States
- Language:
- English
Similar Records
Index, comprehensive microsatellite, and unified linkage maps of human chromosome 14 with cytogenetic tie points and a telomere microsatellite marker
Dinucleotide repeat loci contribute highly informative genetic markers to the human chromosome 2 linkage map