(Inborn anemias of mice): Terminal progress report

Technical Report · Thu Jan 01 00:00:00 EST 1987

OSTI ID:6590085

Bernstein, S E

Mutations located at 11 different chromosomal locations in the mouse all affecting hemopoiesis have been studied. These include: Hertwig's anemia (an), W-anemias (W, W/sup v/, W/sup 17J/ to W/sup 41J/), Steel anemias (Sl, Sl/sup d/, etc.), Normoblastic anemia (nb), Jaundiced (ja), Spherocytic anemias (sph, sph/sup ha/), sph/sup 2J/, sph/sup 2BC/, Flexed-tail anemia (f), Microcytic anemia (mk), Sex-linked anemia (Sla), Alpha thallasemia (Hba/sup th/), and a hypochromic anemia associated with low transferrin levels (hpx). Our findings indicate that the erythroid defect in W-anemias stem from an intrinsic defect in the erythroid progenitor cells, and that all other erythroid hemostatic mechanisms are fully functional. Hertwig's anemia (an) is affected in a similar fashion. However, in the case of Steel anemias, the erythroid progenitors are repressed, but when transplanted to appropriate recipients were found to be fully functional. 70 refs., 4 tabs.

• Research Organization: Jackson Lab., Bar Harbor, ME (USA)
• DOE Contract Number: AC02-76EV03264
• OSTI ID: 6590085
• Report Number(s): DOE/EV/03264-1; ON: DE87009259
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ERYTHROPOIESIS
GENE REGULATION
STEM CELLS
BIOLOGICAL MODELS
ANEMIAS
GENETIC MAPPING
HEREDITARY DISEASES
MICE
MUTANTS
ANIMAL CELLS
ANIMALS
BLOOD FORMATION
DISEASES
HEMIC DISEASES
MAMMALS
MAPPING
RODENTS
SOMATIC CELLS
SYMPTOMS
VERTEBRATES
550900* - Pathology
550400 - Genetics
550200 - Biochemistry