Inborn anemias in mice: (Annual report, 1981-1982)
Hereditary anemias of mice are the chief objects of investigation, specificially four macrocytic anemias, 3 types of hemolytic anemia, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, the autoimmune hemolytic anemia of NZB mice, an ..cap alpha..-thalassemia and a new hypochromic anemia with hemochromatosis. New types of anemia may be analyzed as new mutations appear. Three new mutations have been identified during the past 18 months. These anemias are studied through characterization of peripheral blood values, determinations of radiosensitivity under a variety of conditions, measurements of iron metabolism and heme synthesis, study of normal and abnormal erythrocyte membrane proteins, histological and biochemical characterization of blood-forming tissue, functional tests of the stem-cell component, examination of responses to erythroid stimuli, and transplantation of tissue and parabiosis between individuals of differently affected genotypes. 31 refs.
- Research Organization:
- Jackson Lab., Bar Harbor, ME (USA)
- DOE Contract Number:
- AC02-76EV03264
- OSTI ID:
- 6473569
- Report Number(s):
- DOE/EV/03264-T4; ON: DE87010459
- Country of Publication:
- United States
- Language:
- English
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Inborn anemias in mice
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