Effects of X-irradiation on artificial blood vessel wall degradation by invasive tumor cells
Artificial vessel wall cultures, constructed by growing arterial endothelial cells on preformed layers of rat smooth muscle cells, were used to evaluate the effects of X-irradiation on tumor cell-induced tissue degradation. Bovine endothelial cells had radiation sensitivities similar to those of rat smooth muscle cells. Preirradiation of smooth muscle cells, before the addition of human fibrosarcoma (HT 1080) cells, did not increase the rate of degradation and destruction by the invasive cells. However, the degradation rate was decreased if the cultures were irradiated after the addition of HT 1080 cells. The presence of bovine endothelial cells markedly inhibited the destructive abilities of fibrosarcoma cells, but preirradiation of artificial vessel walls substantially decreased their capabilities to resist HT 1080-induced lysis. These findings suggest that the abilities of blood vessels to limit extravasation may be compromised by ionizing radiation.
- Research Organization:
- Univ. of Southern California, Los Angeles
- OSTI ID:
- 6539704
- Journal Information:
- Cancer Res.; (United States), Vol. 44:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ARTIFICIAL ORGANS
EXTERNAL IRRADIATION
RADIOSENSITIVITY
LYSIS
INHIBITION
TUMOR CELLS
BIOLOGICAL RADIATION EFFECTS
ARTERIES
CATTLE
CELL CULTURES
CELL KILLING
DOSE-RESPONSE RELATIONSHIPS
ENDOTHELIUM
FIBROSARCOMAS
X RADIATION
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DISEASES
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RUMINANTS
SARCOMAS
TISSUES
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)