Effects of low levels of dietary lead and iron on hepatic RNA, protein, and minerals in young Japanese quail
Day-old Japanese quail were fed purified diets containing either 0.2 (control), 5.4, or 16.2 ppm lead as the acetate with either 25 (deficient) or 100 ppm (adequate control) iron for 2 weeks. Iron deficiency caused decreases in hemoglobin, iron, and manganese concentrations in the liver, and hepatic RNA synthesis. Iron deficiency also caused increased concentrations of lead, calcium, and molybdenum in the liver. Lead supplements caused increased concentrations of lead in the liver, and with adequate dietary iron, each supplemental lead level caused a slight decrease in the concentration of RNA in the liver. Treatment had no effect on DNA or protein synthesis, body weight, or liver weight in relation to body weight. These low levels of dietary lead did not cause the same adverse metabolic effects observed by others with higher levels of lead; however, iron deficiency increased lead uptake by the liver and affected RNA synthesis. 44 references.
- Research Organization:
- Food and Drug Administration, Washington, DC
- OSTI ID:
- 6537027
- Journal Information:
- Environ. Res.; (United States), Vol. 33:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IRON
NUTRITIONAL DEFICIENCY
LEAD
BIOLOGICAL EFFECTS
CHEMISORPTION
INGESTION
RETENTION
RNA
BIOSYNTHESIS
CALCIUM
CONCENTRATION RATIO
FOWL
LIVER
MANGANESE
MOLYBDENUM
PROTEINS
RESPONSE MODIFYING FACTORS
WEIGHT
ALKALINE EARTH METALS
ANIMALS
BIRDS
BODY
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
INTAKE
METALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
SEPARATION PROCESSES
SORPTION
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)