In vivo ethanol elimination in man, monkey and rat: A lack of relationship between the ethanol metabolism and the hepatic activities of alcohol and aldehyde dehydrogenases

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90108-4· OSTI ID:6518867

Zorzano, A ^[1]; Herrera, E ^[2]

---

1. Universidad de Barcelona (Spain)
2. Universidad de Madrid (Spain)

The in vivo ethanol elimination in human subjects, monkeys and rats was investigated after an oral ethanol dosage. After 0.4 g. ethanol/kg of body weight, ethanol elimination was much slower in human subjects than in monkeys. In order to detect a rise in monkey plasma ethanol concentrations as early as observed in human subjects, ethanol had to be administered at a dose of 3 g/kg body weight. Ethanol metabolism in rats was also much faster than in human subjects. However, human liver showed higher alcohol dehydrogenase activity and higher low Km aldehyde dehydrogenase activity than rat liver. Thus, our data suggest a lack of relationship between hepatic ethanol-metabolizing activities and the in vivo ethanol elimination rate.

• OSTI ID: 6518867
• Journal Information: Life Sciences; (USA), Vol. 46:3; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOL DEHYDROGENASE
ENZYME ACTIVITY
ETHANOL
METABOLISM
GENETIC VARIABILITY
IN VIVO
LIVER
MAN
MONKEYS
RATS
ALCOHOLS
ANIMALS
BIOLOGICAL VARIABILITY
BODY
DIGESTIVE SYSTEM
ENZYMES
GLANDS
HEMIACETAL DEHYDROGENASES
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PRIMATES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology