In vitro inactivation of hepatic alcohol dehydrogenase and aldehyde dehydrogenases from rats by dithiocarbamates with or without metals

Journal Article · Sat Oct 01 04:00:00 EDT 1988 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF02020998· OSTI ID:6143040

Freundt, K J; Schreiner, E

Alcohol dehydrogenases is localized mainly in the hepatic cytoplasm. Aldehyde dehydrogenases are bound predominantly to the hepatic mitochondrial and endoplasmic reticular membranes; a small part of their total activity is measured in the cytosol. ALDH catalyses the oxidation of acetaldehyde to acetic acid and the metabolism of endogenous or exogenous aldehydes. The goal of the present investigation was to examine in vitro the possible interaction of metal containing dithiocarbamates with the activity of ALDH isolated from rat livers in comparison with that of dithiocarbamates without metals. In addition, the elucidation of an inhibitory effect on isolated liver ADH possibly caused by dithiocarbamates with or without metals could help to explain a previously found delay of ethanol elimination from rat blood. To this end the following substances were tested: The dimers TMTD and TETD, the monomers dimethyldithiocarbamate (DMDC) as sodium salt or as zinc salt and diethyldithiocarbamate (DEDC) as sodium salt, as well as the related compounds tetramethylthiuram monosulfide (TMTM), manganese(II)-(N,N'-ethylenebis(dithiocarbamate)), and zinc-(N,N'-ethylenebis(dithiocarbamate)).

• Research Organization: Univ. of Heidelberg, Mannheim (Germany, F.R.)
• OSTI ID: 6143040
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 41:4; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOL DEHYDROGENASE
ALDEHYDES
ALKALI METAL COMPOUNDS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CHEMISTRY
DIGESTIVE SYSTEM
ELEMENTS
ENZYMES
GLANDS
HEMIACETAL DEHYDROGENASES
INACTIVATION
LIVER
MAMMALS
MANGANESE COMPOUNDS
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RODENTS
SODIUM COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
ZINC COMPOUNDS