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Comparative effects of ten dithiocarbamate and thiuram compounds on tissue distribution and excretion of lead in rats

Journal Article · · Environ. Res.; (United States)
The dithiocarbamate and thiuram compounds, including disulfiram, were compared for their efficacies in influencing tissue distribution of a trace dose of intravenously injected lead plus /sup 203/Pb in rats. The tested compounds were sodium diethyldithiocarbamate (DEDTC), sodium dimethyldithiocarbamate (DMDTC), tetraethylthiuram disulfide (disulfiram), a complex of zinc and manganese ethylenebisdithiocarbamate (mancozeb), manganese ethylenebisdithiocarbamate (maneb), sodium monomethyldithiocarbamate (metham), zinc propylene bisdithiocarbamate (propineb), tetramethylthiuram disulfide (thiram), zinc ethylenebisdithiocarbamate (zineb), and zinc dimethyldithiocarbamate (ziram). The results of this study show that interactions can occur between lead and DEDTC, DMDTC, disulfiram, metham, thiram, and ziram, resulting in increased levels of lead in brain and probably potentiation of the neurotoxic effects of lead.
Research Organization:
National Institute of Environmental Medicine, Stockholm, Sweden
OSTI ID:
5238420
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 44:1; ISSN ENVRA
Country of Publication:
United States
Language:
English

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