Induction of lymphoma and osteosarcoma in mice by single and protracted low alpha doses

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Health Physics; (USA)

DOI:https://doi.org/10.1097/00004032-199009000-00006· OSTI ID:6508809

Mueller, W A.L.; Luz, A; Murray, A B; Linzner, U ^[1]

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1. Gesellschaft fuer Strahlen- und Umweltforschung, Neuherberg (Germany, F.R.)

Internal doses from the short-lived alpha-emitter 22Ra were given to 4-wk-old female mice. One group of about 300 animals received a single injection of 18.5 kBq 22Ra kg-1 body weight, corresponding to a mean skeletal alpha dose of 0.15 Gy. A second group of about 300 animals received the same total amount of 224Ra in the form of 72 fractions of 257 Bq kg-1 each, applied twice weekly during 36 wk. The fractionated group received the same final mean total skeletal dose of 0.15 Gy as the single injected group, but with a mean skeletal dose rate of 1 mGy d-1. A rather high incidence, 13.5% (40/296), of early malignant lymphomas was observed in the fractionated group during and shortly after the injection period, followed by a 7% incidence (21/296) of osteosarcomas during the second half of the animals' lifetime. The group with a single injection did not develop early lymphomas but did develop osteosarcomas later with an incidence of 5.8% (17/295). The occurrence of osteosarcomas was similar up to day 800 in the two experimental groups. Surprisingly, however, after this period no additional case of osteosarcoma was observed in the single-injected group, whereas one-third of all osteosarcomas occurred after day 800 in the protracted group. The additional later occurrence of osteosarcomas occurred after indicates a longer lasting induction effect on osteosarcomas, or a promoting effect in older age, for this kind of treatment.

• OSTI ID: 6508809
• Journal Information: Health Physics; (USA), Vol. 59:3; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOMAS
RADIOINDUCTION
OSTEOSARCOMAS
RADIUM ISOTOPES
CARCINOGENESIS
ACUTE IRRADIATION
BIOLOGICAL RADIATION EFFECTS
FRACTIONATED IRRADIATION
INTRAPERITONEAL INJECTION
LOW DOSE IRRADIATION
MICE
ACUTE EXPOSURE
ALKALINE EARTH ISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
DISEASES
IMMUNE SYSTEM DISEASES
INJECTION
INTAKE
IRRADIATION
ISOTOPES
MAMMALS
NEOPLASMS
PATHOGENESIS
RADIATION EFFECTS
RODENTS
SARCOMAS
SKELETAL DISEASES
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells