Inducible pathway is required for mutagenesis in Salmonella typhimurium LT2

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · J. Bacteriol.; (United States)

OSTI ID:6498595

Orrego, C; Eisenstadt, E

UV mutability of Salmonella typhimurium LT2 was eliminated in the presence of a multicopy plasmid carrying the Escherichia coli lexA/sup +/ gene. This result suggests that inducible, SOS-like functions are required for UV mutagenesis in S. typhimurium. S. typhimurium strains carrying either point or deletion mutations in topA had previously been shown to lose their mutability by UV or methyl methanesulfonate. Mitomycin C induction of the Phi(mucB'-lacZ') fusion (a DNA damage-inducible locus carried on plasmid pSE205) in S. typhimurium topA was normal, suggesting that RecA is activated in topA mutants. These observations lead the authors deduce that S. typhimurium has at least one DNA damage-inducible locus in addition to recA that is required for UV mutability.

• Research Organization: Harvard School of Public Health, Boston, MA
• OSTI ID: 6498595
• Journal Information: J. Bacteriol.; (United States), Vol. 169:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GENE MUTATIONS
RADIOINDUCTION
SALMONELLA TYPHIMURIUM
GENETIC RADIATION EFFECTS
ULTRAVIOLET RADIATION
MUTAGENESIS
BIOLOGICAL PATHWAYS
DNA
GENES
MUTANTS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
MICROORGANISMS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
SALMONELLA
560130* - Radiation Effects on Microorganisms