Polychlorinated biphenyl (PCB) partitioning between adipose tissue and serum
It has been recently suggested that variabilities in the partitioning of chronically retained lipophilic xenobiotics between adipose tissue and serum may be relatable to variations in the lipid content of the serum. Here, the authors present theoretical considerations and experimental data showing that this is indeed the case for polychlorinated biphenyls (PCBs) in humans. At equilibrium, in the absence of active transport, any lipophilic substance must distribute itself among body tissues in such a way that its chemical activity and also its chemical potential are the same at all points. In order to verify the theoretical relationships, three sorts of data relating to serum PCB levels in a human population were examined.
- Research Organization:
- General Electric Research and Development Center, Schenectady, NY
- OSTI ID:
- 6498122
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 33:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL ACCUMULATION
THERMODYNAMIC ACTIVITY
ADIPOSE TISSUE
BLOOD SERUM
MATHEMATICAL MODELS
PARTITION FUNCTIONS
PERSONNEL
ANIMAL TISSUES
AROMATICS
BODY
CONNECTIVE TISSUE
FUNCTIONS
HALOGENATED AROMATIC HYDROCARBONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
TISSUES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)