Influence of serum cholesterol and albumin on partitioning of PCB congeners between human serum and adipose tissue

Journal Article · Wed Dec 31 23:00:00 EST 1986 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(87)90083-4· OSTI ID:6927257

Guo, Y L; Emmett, E A; Pellizzari, E D; Rohde, C A

The influence of serum lipids and proteins on partitioning of individual polychlorinated biphenyl (PCB) congener peaks between human serum and adipose tissue lipid was assessed using regression analysis. Subjects were 55 repair workers who were either currently or previously exposed, and 56 comparison workers without occupational exposure to PCBs. Seven congeners (2,4,5,4'-tetra CB, 2,3,5,2',3',6'-hexa CB, 2,3,4,2'3',6'-hexa CB, 2,3,4,2'4',5'-hexa CB, 3,4,5,3',4'-penta CB, 2,3,4,5,2',3',4'-hepta CB, and 2,3,4,5,2',3',4',5'-octa CB) which had been quantified in both serum and adipose tissue in at least one-third of the total study population were selected for evaluation. Initially the crude correlations between the serum PCB and certain candidate variables were assessed; more than one congener was correlated with serum cholesterol, albumin, triglycerides, low-density lipoproteins, ver low-density lipoproteins, age, body fat content, and average servings of fish per day. Stepwise regression of log serum congener concentration on long adipose congener concentration and these variables was performed. Only cholesterol, albumin, and average servings of fish per day were significant for at least one congener peak. Congeners behaved in two groups, depending on their order of chromatographic elution. For 2,4,5,4'-tetra CB, 2,3,5,2',3',6'-hexa CB, and 2,3,4,2',3',6'-hexa CB, log serum concentration was not significantly correlated with log adipose congener concentration, and there ws no consistent pattrn for significant candidate variables. For congeners 2,3,4,2',4',5'-hexa CB, 3,4,5,3',4'-penta CB, 2,3,4,5,2',3',4'-hepta CB, and 2,3,4,5,2',3',4',5'-octa CB, log serum congener concentration was consistently significantly correlated with log adipose congener concentration and serum cholesterol positively, and with serum albumin negatively.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 6927257
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 1; ISSN TXAPA
• Country of Publication: United States
• Language: English

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ALBUMINS
ANIMAL TISSUES
ANIMALS
AQUATIC ORGANISMS
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BLOOD SERUM
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CHROMATOGRAPHY
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OCCUPATIONAL EXPOSURE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PERSONNEL
PROTEINS
REACTION KINETICS
REGRESSION ANALYSIS
SEPARATION PROCESSES
STATISTICS
STEROIDS
STEROLS
TISSUE DISTRIBUTION
TISSUES
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