Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract

Journal Article · · J. Agric. Food Chem.; (United States)

DOI:https://doi.org/10.1021/jf00061a007· OSTI ID:7009641

Safe, S; Safe, L; Mullin, M

On the basis of the relative retention times and response factors of all 209 synthetic polychlorinated biphenyls (PCBs), this paper reports the first congener-specific analysis of a commercial PCB preparation, Aroclor 1260, and PCB composition of a human milk extract. The analysis indicates that Aroclor 1260 contains nearly 80 different PCB congeners with the major components identified as 2,2',3,4',5',6-,2,2',4,4',5,5'-, 2,2',3,4,5,5'-, and 2,2',3,4,4',5'-haxachlorobiphenyl and 2,2',3,3',4,4',5-, 2,2'3,3'4,5,6'-, 2,2'3,4,4',5,5'-, and 2,2',3,4',5,5',6-heptachlorobiphenyl. In contrast, the major PCB components of the human milk fraction were the 2,4,4'-tri,2,4,4',5-tetra-,2,2',4,4',5-penta-,2,3',4,4',5-penta-,2,2',3,4,4',5'-hexa-,2,2',4,4',5,5'-hexa-,2,2',3,3',4,4',5-hepta-, and 2,2',3,4,4',5-heptachlorobiphenyls. The significance of congener-specific PCB analysis is discussed in terms of the structure-activity effects on PCB persistence, bioaccumulation, and toxicity.

• Research Organization: Texas A and M Univ., College Station
• OSTI ID: 7009641
• Journal Information: J. Agric. Food Chem.; (United States), Journal Name: J. Agric. Food Chem.; (United States) Vol. 33:1; ISSN JAFCA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BODY FLUIDS
CHEMICAL ANALYSIS
CHLORINATED AROMATIC HYDROCARBONS
FOOD
HALOGENATED AROMATIC HYDROCARBONS
MAMMALS
MAN
MATERIALS
MILK
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
STRUCTURE-ACTIVITY RELATIONSHIPS
TOXICITY
VERTEBRATES