Breast screening with mammography: Overview of Swedish randomized trials

Journal Article · Sat Apr 17 00:00:00 EDT 1993 · Lancet; (United States)

DOI:https://doi.org/10.1016/0140-6736(93)91067-V· OSTI ID:6399754

Nystroem, L; Wall, S ^[1]; Rutqvist, L E ^[2]; Lindgren, A ^[3]; Lindqvist, M ^[4]; Ryden, S ^[5]; Andersson, J ^[6]; Bjurstam, N ^[7]; Fagerberg, G ^[8]; Frisell, J ^[9]; Tabar, L ^[10]; Larson, L G ^[11]

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1. Umea Univ. (Sweden). Dept. of Epidemiology and Public Health
2. Karolinska Hospital, Stockholm (Sweden). Oncologic Centre
3. Academic Hospital, Uppsala (Sweden)
4. Karolinska Hospital, Stockholm (Sweden)
5. Angelholm Hospital (Sweden)
6. Malmoe Hospital (Sweden)
7. Sahlgrenska Hospital, Gothenburg (Sweden)
8. Univ. Hospital, Linkoeping (Sweden)
9. South Hospital, Stockholm (Sweden)
10. Falun Hospital (Sweden)
11. Umea Univ. Hospital (Sweden). Oncologic Centre

Despite encouraging results from screening trials the efficacy of mammography in reducing mortality remains somewhat controversial. Five studies have been done in Sweden. This overview, reveals a 24% significant reduction of breast cancer mortality among those invited to mammography screening compared with those not invited. To avoid the potential risk of differential misclassification causes of death were assessed by an independent end-point committee after a blinded review of all fatal breast cancer cases. The mortality reduction was similar, irrespective of the end-point used for evaluation (breast cancer as underlying cause of death or breast cancer present at death). There was a consistent risk reduction associated with screening in all studies, although the point estimate of the relative risk for all ages varied non-significantly between 0.68 and 0.84. The cumulative breast cancer mortality by time since randomization was estimated at 1.3 per 1,000 within 6 years in the invited group compared with 1.6 in the control group. The corresponding figures after 9 years are 2.6 and 3.3 and after 12 years 3.9 and 5.1.

• OSTI ID: 6399754
• Journal Information: Lancet; (United States), Vol. 341:8851; ISSN 0099-5355
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MAMMARY GLANDS
NEOPLASMS
DIAGNOSIS
AGE DEPENDENCE
BIOMEDICAL RADIOGRAPHY
MORTALITY
SWEDEN
WOMEN
ANIMALS
BODY
DEVELOPED COUNTRIES
DIAGNOSTIC TECHNIQUES
DISEASES
EUROPE
FEMALES
GLANDS
MAMMALS
MAN
MEDICINE
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIOLOGY
SCANDINAVIA
VERTEBRATES
WESTERN EUROPE
550602* - Medicine- External Radiation in Diagnostics- (1980-)