Intravascular contrast agents suitable for magnetic resonance imaging. [Dogs]

Journal Article · Mon Oct 01 00:00:00 EDT 1984 · Radiology; (United States)

OSTI ID:6334724

Runge, V M; Clanton, J A; Herzer, W A; Gibbs, S J; Price, A C; Partain, C L; James, Jr, A E

Two paramagnetic chelates, chromium EDTA and gadolinium DTPA, were evaluated as potential intravenous contrast agents for magnetic resonance imaging. After evaluating both agents in vitro, in vivo studies were conducted in dogs to document changes in renal appearance produced by contrast injection. Acute splenic and renal infarction were diagnosed with contrast-enhanced MR and confirmed by gamma camera imaging following administration of Tc-99m-labeled DMSA and sulfur colloid. The authors conclude that intravenous paramagnetic contrast agents presently offer the best mechanism for assessment of tissue function and changes in perfusion with MR.

• Research Organization: Vanderbilt Univ. Medical Center, Nashville, TN
• OSTI ID: 6334724
• Journal Information: Radiology; (United States), Vol. 153:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ISCHEMIA
DIAGNOSIS
KIDNEYS
MAGNETIC RESONANCE
SCINTISCANNING
SPLEEN
TECHNETIUM 99
CHELATES
CHROMIUM COMPLEXES
DOGS
DTPA
EDTA
GADOLINIUM COMPLEXES
IN VITRO
IN VIVO
ISOMERIC NUCLEI
RADIOCOLLOIDS
SULFUR COMPOUNDS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CHELATING AGENTS
COLLOIDS
COMPLEXES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RARE EARTH COMPLEXES
RESONANCE
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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