Contrast enhancement of magnetic resonance images by chromium EDTA: an experimental study. [Rabbits; Rats]

Journal Article · Sun Jul 01 04:00:00 EDT 1984 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.152.1.6427845· OSTI ID:6659883

Runge, V M; Foster, M A; Clanton, J A; Jones, M M; Lukehart, C M; Hutchison, J M.S.; Mallard, J R; Path, F R.C.; Smith, F W; Partain, C L

Chromium EDTA was evaluated as an intravenous contrast agent for magnetic resonance (MR) imaging in vitro and in vivo in rabbits and rats. Following administration of chromium EDTA, differences in T1 values between normal and abnormal kidneys were noted, renal hydronephrosis and renal ischemia were readily identified by the pattern of change in T1, and changes were observed in the normal rabbit brain and in tumors implanted in rats. It is concluded that the use of stable paramagnetic metal ion chelates, such as Cr EDTA, as intravenous contrast agents in MR imaging is feasible and that such agents would make possible the observation of tissue vascularity, breakdown of the blood-brain barrier, and renal function.

• Research Organization: Vanderbilt Univ., Nashville, TN
• OSTI ID: 6659883
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 152:1; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CONTRAST MEDIA
DISEASES
EDTA
EVALUATION
IN VITRO
IN VIVO
KIDNEYS
MAGNETIC RESONANCE
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MAGNETIC RESONANCE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RABBITS
RATS
RELAXATION
RESONANCE
RODENTS
SPIN-LATTICE RELAXATION
SPIN-SPIN RELAXATION
UROGENITAL SYSTEM DISEASES
VERTEBRATES