Effects of lindane on the glucose metabolism in rat brain cortex cells

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90168-Q· OSTI ID:6291133

Pulido, J A; del Hoyo, N; Perez-Albarsanz, M A ^[1]

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1. Univ. of Alcala, Madrid (Spain)

The influence of 0.5 mM {gamma}-hexachlorocyclohexane ({gamma}-HCH, lindane) on glucose transport has been investigated using the analog 3-O-methyl-D(U-{sup 14}C) glucose. The glucose uptake was lineal for at least 10 sec. Preincubation of dissociated brain cortex cells with lindane decreased the transport of glucose with respect to the controls. The treatment of brain cortex cells with other organochlorine compounds indicated that the {alpha}-, {delta}-HCH isomers and dieldrin reproduced the same inhibitory pattern, while {beta}-HCH and endrin were inactive. The total radioactivity incorporated into CO{sub 2} from (U-{sup 14}C) glucose in the cerebral cortex is also inhibited by lindane in a time dependent manner.

• OSTI ID: 6291133
• Journal Information: Life Sciences; (USA), Vol. 47:13; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GLUCOSE
METABOLISM
LINDANE
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
CEREBRAL CORTEX
MEMBRANE TRANSPORT
ORGANIC CHLORINE COMPOUNDS
TIME DEPENDENCE
TRACER TECHNIQUES
ALDEHYDES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHLORINATED ALICYCLIC HYDROCARBONS
HALOGENATED ALICYCLIC HYDROCARBONS
HEXOSES
INSECTICIDES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
SACCHARIDES
550501* - Metabolism- Tracer Techniques