Correlations between uptake of technetium, calcium, phosphate, and mineralization in rat tibial bone repair
- Hebrew Univ.-Hadassah School of Medicine, Jerusalem (Israel)
Technetium-99m-({sup 99m}Tc) phosphates are extensively used for detection of bone formation and resorption. The present is a study of {sup 99m}Tc incorporation during bone remodeling. Uptake of {sup 99m}Tc-labeled phosphate was studied in an animal model of primary osteogenesis following tibial marrow injury and incorporation was correlated to that of calcium-47 ({sup 47}Ca), phosphorus-32 ({sup 32}P), and with matrix vesicle calcification. Isotope uptake on Day 6 in the whole bone was increased compared to controls. On this day, an increase in vesicular diameter and distance from the calcified front was previously observed. Technetium-99m-labeled phosphates were detected only in the organic phase. Phosphorus-32 and {sup 47}Ca were detected in both organic and inorganic phases. It is suggested that {sup 99m}Tc serves as a specific marker to the anabolic phase of remodeling. Increased incorporation of {sup 99m}Tc during bone healing indicates enhanced organic matrix formation and not calcification.
- OSTI ID:
- 6210050
- Journal Information:
- Journal of Nuclear Medicine; (USA), Vol. 31:12; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CALCIUM
UPTAKE
PHOSPHATES
SKELETON
BIOLOGICAL REPAIR
TECHNETIUM 99
BIOLOGICAL MARKERS
CALCIUM 47
HEALING
ISOMERIC NUCLEI
MINERALIZATION
RATS
SKELETAL DISEASES
TRACER TECHNIQUES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BODY
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELEMENTS
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RADIOISOTOPES
RECOVERY
REPAIR
RODENTS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550901* - Pathology- Tracer Techniques
560162 - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells