Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience

Journal Article · Sun Jul 01 00:00:00 EDT 1984 · J. Clin. Oncol.; (United States)

OSTI ID:6201535

Tester, W J; Kinsella, T J; Waller, B; Makuch, R W; Kelley, P A; Glatstein, E; DeVita, V T

The medical records of all patients treated for Hodgkin's disease during the years 1964-1981 were reviewed. Four hundred seventy-three previously untreated patients were analyzed. Thirty-four subsequent second malignant neoplasms were observed in 33 patients among those treated for Hodgkin's disease. Eight cases of acute nonlymphocyctic leukemia, one case of chronic myeloid leukemia, three cases of non-Hodgkin's lymphoma, three cases of sarcoma, and 19 other tumors were identified. The ten-year estimated risk of leukemia by treatment was the following: radiotherapy only (0), chemotherapy only (0.02), initial combined radiotherapy-chemotherapy (0.06), and salvage combined radiotherapy-chemotherapy (0.09). The ten-year estimated risk of solid tumors was 0.07 overall, with all treatment groups associated with similar risks. Unlike some other reports, a greater risk of leukemia in patients who began treatment for Hodgkin's disease at age 40 or older was not found. However, a positive association was noted between increasing risk of solid tumors and increasing patient age.

• Research Organization: National Cancer Inst., Bethesda, MD
• OSTI ID: 6201535
• Journal Information: J. Clin. Oncol.; (United States), Vol. 2:7
• Country of Publication: United States
• Language: English

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