Second malignancies complicating Hodgkin's disease: a Southwest Oncology Group 10-year followup
Journal Article
·
· Cancer Treat. Rep.; (United States)
OSTI ID:7054684
Thirty-two second malignancies (21 acute leukemias and 11 solid tumors) were identified among 659 patients with all stages of Hodgkin's disease treated by members of the Southwest Oncology Group. There were no leukemias and one solid tumor among 95 patients treated with radiotherapy alone. The actuarial risk of developing acute leukemia at 7 years was 6.2% for chemotherapy alone, 6.4% for combined modality, and 7.7% for salvage chemotherapy. The incidence of acute leukemia was higher (P . 0.002) among those whose treatment began at greater than or equal to 40 years of age. The actuarial risk of leukemia in that group was 20.7% at 7 years. These data are compatible with the hypothesis that chemotherapy alone, combined modality, and salvage chemotherapy have an equivalent oncogenic potential and that patients greater than or equal to 40 years of age have an enhanced susceptibility to these oncogenic stimuli.
- Research Organization:
- University of Texas Health Sciences Center at San Antonio
- OSTI ID:
- 7054684
- Journal Information:
- Cancer Treat. Rep.; (United States), Journal Name: Cancer Treat. Rep.; (United States) Vol. 66:4; ISSN CTRRD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
DISEASES
HEMIC DISEASES
HODGKINS DISEASE
LEUKEMIA
LYMPHOMAS
MATHEMATICS
MEDICAL SURVEILLANCE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ONCOGENIC TRANSFORMATIONS
PATHOGENESIS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
STATISTICS
SURVEILLANCE
THERAPY
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
DISEASES
HEMIC DISEASES
HODGKINS DISEASE
LEUKEMIA
LYMPHOMAS
MATHEMATICS
MEDICAL SURVEILLANCE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ONCOGENIC TRANSFORMATIONS
PATHOGENESIS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
STATISTICS
SURVEILLANCE
THERAPY