Occurrence of non-Hodgkin's lymphoma after therapy for Hodgkin's disease. [Incidence following combined chemotherapy and radiotherapy]
We studied the clinical and pathological features of six cases of non-Hodgkin's lymphoma occuring in patients treated for Hodgkin's disease. All six patients had received both radiation therapy and chemotherapy. Abdominal or gastrointestinal involvement was present in five of the six cases. None of the patients had evidence of Hodgkin's disease when the diagnosis of non-Hodgkin's lymphoma was made. Five of the six patients were among a study group of 579 patients with Hodgkin's disease, prospectively followed since diagnosis. At 10 years the actuarial risk of development of non-Hodgkin's lymphoma in this study group is 4.4 per cent and is similar to that of developing acute leukemia: 2.0 per cent. Non-Hodgkin's lymphoma is a second tumor that may occur late in the course of patients treated for Hodgkin's disease, particularly in patients who have received both radiation therapy and chemotherapy. Like acute leukemia, non-Hodgkin's lymphoma may be another cancer that represents a substantial late risk of combined-modality therapy.
- OSTI ID:
- 6294423
- Journal Information:
- New Engl. J. Med.; (United States), Vol. 300:9
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
DELAYED RADIATION EFFECTS
CARCINOGENESIS
RISK ASSESSMENT
CHEMOTHERAPY
RADIOSENSITIVITY EFFECTS
SIDE EFFECTS
GASTROINTESTINAL TRACT
HODGKINS DISEASE
RADIOTHERAPY
LYMPHOMAS
RADIOINDUCTION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
PARTIAL BODY IRRADIATION
PATIENTS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DIGESTIVE SYSTEM
DISEASES
EXTERNAL IRRADIATION
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)