Occurrence of non-Hodgkin's lymphoma after therapy for Hodgkin's disease. [Incidence following combined chemotherapy and radiotherapy]
Journal Article
·
· New Engl. J. Med.; (United States)
We studied the clinical and pathological features of six cases of non-Hodgkin's lymphoma occuring in patients treated for Hodgkin's disease. All six patients had received both radiation therapy and chemotherapy. Abdominal or gastrointestinal involvement was present in five of the six cases. None of the patients had evidence of Hodgkin's disease when the diagnosis of non-Hodgkin's lymphoma was made. Five of the six patients were among a study group of 579 patients with Hodgkin's disease, prospectively followed since diagnosis. At 10 years the actuarial risk of development of non-Hodgkin's lymphoma in this study group is 4.4 per cent and is similar to that of developing acute leukemia: 2.0 per cent. Non-Hodgkin's lymphoma is a second tumor that may occur late in the course of patients treated for Hodgkin's disease, particularly in patients who have received both radiation therapy and chemotherapy. Like acute leukemia, non-Hodgkin's lymphoma may be another cancer that represents a substantial late risk of combined-modality therapy.
- OSTI ID:
- 6294423
- Journal Information:
- New Engl. J. Med.; (United States), Journal Name: New Engl. J. Med.; (United States) Vol. 300:9; ISSN NEJMA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Second neoplasms in patients with Hodgkin's disease following combined modality therapy--the Yale experience
Nonrandom chromosomal abnormalities in acute nonlymphocytic leukemia in patients treated for Hodgkin disease and non-Hodgkin lymphomas
Reduction of fatal complications from combined modality therapy in Hodgkin's disease
Journal Article
·
Fri Feb 28 23:00:00 EST 1986
· J. Clin. Oncol.; (United States)
·
OSTI ID:5528637
Nonrandom chromosomal abnormalities in acute nonlymphocytic leukemia in patients treated for Hodgkin disease and non-Hodgkin lymphomas
Journal Article
·
Mon Oct 31 23:00:00 EST 1977
· Blood; (United States)
·
OSTI ID:7287115
Reduction of fatal complications from combined modality therapy in Hodgkin's disease
Journal Article
·
Sun Mar 31 23:00:00 EST 1985
· J. Clin. Oncol.; (United States)
·
OSTI ID:5566380
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOGENESIS
CHEMOTHERAPY
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
HODGKINS DISEASE
IONIZING RADIATIONS
IRRADIATION
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PARTIAL BODY IRRADIATION
PATHOGENESIS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
THERAPY
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOGENESIS
CHEMOTHERAPY
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
HODGKINS DISEASE
IONIZING RADIATIONS
IRRADIATION
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PARTIAL BODY IRRADIATION
PATHOGENESIS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
THERAPY