Comparison of N-isopropyl (/sup 123/I) p-iodoamphetamine brain scans using Anger camera scintigraphy and single-photon emission tomography
N-isopropyl (/sup 123/I) p-iodoamphetamine (IMP), which is extracted by the brain in proportion to regional blood flow, has been shown to be useful with single-photon emission tomography (SPECT) in the assessment of pathologic states related to blood flow. Because emission tomographic equipment is not yet available at most hospitals, the authors compared IMP brain images obtained with an Anger camera with those obtained by SPECT to determine the usefulness of IMP scintigraphy. Thirty-nine pairs of studies were performed on 12 control patients, 14 patients with stroke, three patients with tumors, and a miscellaneous group of eight patients. Planar scintigraphy showed good correlation with SPECT in determining the presence or absence of abnormality in all patients except one with a very small brain stem infarction that was not detected by planar imaging. Anger images showed poor contrast resolution compared with SPECT images. It is thus expected that SPECT will result in better lesion detection when smaller lesions are studied. Planar scintigraphy is not capable of providing quantitative measurement of regional cerebral blood flow.
- Research Organization:
- Department of Radiology, New England Deaconess Hospital, Boston, MA
- OSTI ID:
- 6186365
- Journal Information:
- Radiology; (United States), Vol. 145:3
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BRAIN
SCINTISCANNING
IODINE 123
DIAGNOSTIC USES
VASCULAR DISEASES
DIAGNOSIS
BENZEDRINE
BLOOD FLOW
COMPARATIVE EVALUATIONS
PATHOLOGY
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
AMINES
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPATHOMIMETICS
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques