Threshold-like dose of local beta irradiation repeated throughout the life span of mice for induction of skin and bone tumors
- National Cancer Center Research Institute, Tokyo (Japan)
The backs of female ICR mice were irradiated with beta rays from 90Sr-90Y three times a week throughout life. Previously we observed 100% tumor incidence at five different dose levels ranging from 1.5 to 11.8 Gy per exposure, but no tumor on repeated irradiation with 1.35 Gy for 300 days. In the present study, delay of tumor development was again seen at a dose of 1.5 Gy per exposure, with further delay at 1.0 Gy. The final tumor incidence was 100% with these two doses. At 0.75 Gy per exposure, no tumor appeared within 790 days after the start of irradiation, but one osteosarcoma and one squamous cell carcinoma did finally appear. These findings indicate a threshold-like response of tumor induction in this repeated irradiation system and further suggest that the apparent threshold may be somewhat less than 0.75 Gy per exposure.
- OSTI ID:
- 6143993
- Journal Information:
- Radiation Research; (USA), Vol. 125:1; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOMAS
RADIOINDUCTION
OSTEOSARCOMAS
SKIN
STRONTIUM 90
THRESHOLD DOSE
YTTRIUM 90
FRACTIONATED IRRADIATION
MICE
RADIATION DOSES
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
EVEN-EVEN NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
STRONTIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
YTTRIUM ISOTOPES
560152* - Radiation Effects on Animals- Animals