Mutagenicity studies with urine concentrates from coke plant workers
Urine from coke plant workers, collected before and after work, were tested for the content of mutagenic substances in the Salmonella test system. Urine extracts from exposed smokers showed mutagenic activity, whereas urine from exposed nonsmokers did not. The mutagenicity of exposed smoker's urine was not significantly different from that of urine from nonexposed smokers. Mutagenicity of smokers' urine was only evident in the presence of a rat liver metabolic activation system. The addition of beta-glucuronidase did not enhance the mutagenic effect. The facts that coke plant workers are exposed to very high levels of polycyclic aromatic hydrocarbons (PAH) and that there is no observed enhanced mutagenicity of their urine indicate that the mutagenicity observed with urine from smokers is not due to conventional PAH.
- OSTI ID:
- 6113101
- Journal Information:
- Odontol. Conserv.; (United States), Vol. 6:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
01 COAL, LIGNITE, AND PEAT
COKING PLANTS
HEALTH HAZARDS
TOBACCO SMOKES
URINE
MUTAGEN SCREENING
GLUCURONIDASE
LIVER
METABOLIC ACTIVATION
MUTAGENS
PERSONNEL
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
SALMONELLA TYPHIMURIUM
SAMPLING
AEROSOLS
ANIMALS
AROMATICS
BACTERIA
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
ENZYMES
GLANDS
GLYCOSYL HYDROLASES
HAZARDS
HYDROCARBONS
HYDROLASES
INDUSTRIAL PLANTS
MAMMALS
MATERIALS
MICROORGANISMS
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
RESIDUES
RODENTS
SALMONELLA
SCREENING
SMOKES
SOLS
VERTEBRATES
WASTES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
016000 - Coal
Lignite
& Peat- Health & Safety