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Title: Mutagenicity studies with urine concentrates from coke plant workers

Abstract

Urine from coke plant workers, collected before and after work, were tested for the content of mutagenic substances in the Salmonella test system. Urine extracts from exposed smokers showed mutagenic activity, whereas urine from exposed nonsmokers did not. The mutagenicity of exposed smoker's urine was not significantly different from that of urine from nonexposed smokers. Mutagenicity of smokers' urine was only evident in the presence of a rat liver metabolic activation system. The addition of beta-glucuronidase did not enhance the mutagenic effect. The facts that coke plant workers are exposed to very high levels of polycyclic aromatic hydrocarbons (PAH) and that there is no observed enhanced mutagenicity of their urine indicate that the mutagenicity observed with urine from smokers is not due to conventional PAH.

Authors:
;
Publication Date:
OSTI Identifier:
6113101
Resource Type:
Journal Article
Journal Name:
Odontol. Conserv.; (United States)
Additional Journal Information:
Journal Volume: 6:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 01 COAL, LIGNITE, AND PEAT; COKING PLANTS; HEALTH HAZARDS; TOBACCO SMOKES; URINE; MUTAGEN SCREENING; GLUCURONIDASE; LIVER; METABOLIC ACTIVATION; MUTAGENS; PERSONNEL; POLYCYCLIC AROMATIC HYDROCARBONS; RATS; SALMONELLA TYPHIMURIUM; SAMPLING; AEROSOLS; ANIMALS; AROMATICS; BACTERIA; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; COLLOIDS; DIGESTIVE SYSTEM; DISPERSIONS; ENZYMES; GLANDS; GLYCOSYL HYDROLASES; HAZARDS; HYDROCARBONS; HYDROLASES; INDUSTRIAL PLANTS; MAMMALS; MATERIALS; MICROORGANISMS; O-GLYCOSYL HYDROLASES; ORGANIC COMPOUNDS; ORGANS; RESIDUES; RODENTS; SALMONELLA; SCREENING; SMOKES; SOLS; VERTEBRATES; WASTES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 016000 - Coal, Lignite, & Peat- Health & Safety

Citation Formats

Moeller, M, and Dybing, E. Mutagenicity studies with urine concentrates from coke plant workers. United States: N. p., 1980. Web. doi:10.5271/sjweh.2611.
Moeller, M, & Dybing, E. Mutagenicity studies with urine concentrates from coke plant workers. United States. https://doi.org/10.5271/sjweh.2611
Moeller, M, and Dybing, E. 1980. "Mutagenicity studies with urine concentrates from coke plant workers". United States. https://doi.org/10.5271/sjweh.2611.
@article{osti_6113101,
title = {Mutagenicity studies with urine concentrates from coke plant workers},
author = {Moeller, M and Dybing, E},
abstractNote = {Urine from coke plant workers, collected before and after work, were tested for the content of mutagenic substances in the Salmonella test system. Urine extracts from exposed smokers showed mutagenic activity, whereas urine from exposed nonsmokers did not. The mutagenicity of exposed smoker's urine was not significantly different from that of urine from nonexposed smokers. Mutagenicity of smokers' urine was only evident in the presence of a rat liver metabolic activation system. The addition of beta-glucuronidase did not enhance the mutagenic effect. The facts that coke plant workers are exposed to very high levels of polycyclic aromatic hydrocarbons (PAH) and that there is no observed enhanced mutagenicity of their urine indicate that the mutagenicity observed with urine from smokers is not due to conventional PAH.},
doi = {10.5271/sjweh.2611},
url = {https://www.osti.gov/biblio/6113101}, journal = {Odontol. Conserv.; (United States)},
number = ,
volume = 6:3,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1980},
month = {Tue Jan 01 00:00:00 EST 1980}
}