Evaluation of the SOS chromotest for the detection of antimutagens

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Environmental and Molecular Mutagenesis; (United States)

DOI:https://doi.org/10.1002/em.2850170407· OSTI ID:6092979

Sato, Takahiko; Chikazawa, Kazuhiko; Yamamori, Hidetomo; Ose, Youki; Nagase, Hisamitsu; Kito, Hideaki ^[1]

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1. Gifu Pharmaceutical Univ. (Japan)

The SOS chromotest was applied for the detection of antimutagens. To raise SOS induction, the bacteria were treated with the mutagens, UV, 4-nitroquinoline N-oxide (4NQO), N-methyl-N{prime}-nitro-N-nitroso-guanidine (MNNG), or benzo(a)pyrene (B(a)p). The inhibitory effects of {sub L}-ascorbic acid, glutathione, vanillin,5-fluorouracil (5-FU), 5-chlorouracil (5-CU), cobaltous chloride, sodium selenite and sodium arsenite, which are known as antimutagens, were investigated with their addition either simultaneously or post treatment time. In became clear that the SOS chromotest was very useful for the detection of antimutagens.

• OSTI ID: 6092979
• Journal Information: Environmental and Molecular Mutagenesis; (United States), Vol. 17:4; ISSN 0893-6692
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ESCHERICHIA COLI
ENZYME INDUCTION
MUTAGENS
DOSE-RESPONSE RELATIONSHIPS
MUTATIONS
RADIOINDUCTION
ALKALINE PHOSPHATASE
ARSENIC COMPOUNDS
ASCORBIC ACID
BENZOPYRENE
CHLOROURACILS
COBALT CHLORIDES
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FLUOROURACILS
GALACTOSIDASE
GENETIC RADIATION EFFECTS
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NITROSO COMPOUNDS
QUINOLINES
SELENITES
ULTRAVIOLET RADIATION
ANTIMETABOLITES
AROMATICS
AZAARENES
AZINES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHLORIDES
CHLORINE COMPOUNDS
COBALT COMPOUNDS
CONDENSED AROMATICS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
ESTERASES
GENE REGULATION
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GLYCOSYL HYDROLASES
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYDROLASES
HYDROXY COMPOUNDS
MICROORGANISMS
O-GLYCOSYL HYDROLASES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PEPTIDES
PHOSPHATASES
POLYPEPTIDES
PROTEINS
PYRIDINES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
SCREENING
SELENIUM COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
URACILS
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