Mutagenicity in Salmonella and sister chromatid exchange in mice for 1,4-, and 1,3-, 2,4-, and 3,4-dimethylphenanthrenes

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Environmental and Molecular Mutagenesis; (United States)

DOI:https://doi.org/10.1002/em.2850170205· OSTI ID:6053096

Sinsheimer, J E; Giri, A K; Hooberman, B H; Jung, K Y; Gopalaswamy, R; Koreeda, M ^[1]

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1. Univ. of Michigan, Ann Arbor (United States)

The mutagenicity in Salmonella and in vivo sister chromatid exchange in the bone-marrow cells of mice was determined for 1,4-, 1,3-, 2,4-, and 3,4-dimethylphenanthrene (DMPh) with the objective to study the relative importance of substitution at the 1 and 4 positions of this series of methylated phenanthrenes. For both tests, 1,4-DMPh was decidedly more genotoxic than the remaining regioisomers. While the well recognized role of steric crowding in the bay region is a factor in this enhanced genotoxicity, equally important is substitution at the 1 position with its potential to inhibit detoxication through 9,10-diol formation.

• OSTI ID: 6053096
• Journal Information: Environmental and Molecular Mutagenesis; (United States), Vol. 17:2; ISSN 0893-6692
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
POLYCYCLIC AROMATIC HYDROCARBONS
MUTAGEN SCREENING
SISTER CHROMATID EXCHANGES
DOSE-RESPONSE RELATIONSHIPS
BONE MARROW CELLS
MICE
PHENANTHRENE
SALMONELLA TYPHIMURIUM
ANIMAL CELLS
ANIMALS
AROMATICS
BACTERIA
CHROMOSOMAL ABERRATIONS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
HYDROCARBONS
MAMMALS
MICROORGANISMS
MUTATIONS
ORGANIC COMPOUNDS
RODENTS
SALMONELLA
SCREENING
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology