Effect of oral administration of mutagens found in food on the frequency of sister chromatid exchanges in the colonic epithelium of mice
Epidemiological studies indicate there is a link between dietary factors and the incidence of colon cancer, and it has been suggested mutagens in foods might be responsible for initiating the carcinogenic process. Some food mutagens are formed during the cooking process. For example, certain heterocyclic amines, including Trp-P-2 (3-amino-1-methyl-5H-pyrido(4,3-n) indole) and MeIQ (2-amino-3,4-dimethylimidazo(4,5-f)quinoline), which have been isolated from broiled meat and fish at low (ng/g) levels, are extremely potent mutagens in the Ames Salmonella/microsome test and can induce mutation in cultured mammalian cells as well. Other mutagens in foods are natural products; quercetin, a flavanoid widely distributed in plant products, is mutagenic to Salmonella and cultured mammalian cells. As most of the evidence implicating substance in food as mutagenic carcinogens comes from in vitro studies, it is of interest to determine whether these compounds can also exert genotoxic effects in vivo, particularly in colonic tissue. The ability to induce nuclear aberrations in vivo in murine colonic epithelial tissue has been suggested to be a property of colon carcinogens specifically, and several mutagens found in cooked food, including MeIQ and Trp-P-2, have been found to produce such nucleotoxicity. The authors report here tests of the ability of MeIQ, Trp-P-2, and quercetin to induce sister chromatid exchanges (SCEs) in the colonic epithelium of mice.
- Research Organization:
- Ludwig Institute for Cancer Research, Toronto, Ontario (Canada)
- OSTI ID:
- 5276942
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 10:2; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
AZAARENES
AZINES
AZOLES
BIOLOGICAL EFFECTS
BODY
CHROMOSOMAL ABERRATIONS
DIGESTIVE SYSTEM
EPITHELIUM
FLAVENOIDS
FLAVONES
FOOD
FOOD PROCESSING
GASTROINTESTINAL TRACT
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VIVO
INDOLES
INTESTINES
LARGE INTESTINE
MAMMALS
MICE
MUTAGENS
MUTATIONS
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROCESSING
PYRANS
PYRIDINES
PYRROLES
QUERCETIN
QUINOLINES
RODENTS
SISTER CHROMATID EXCHANGES
TISSUES
VERTEBRATES