Effect of semiconductor GaAs laser irradiation on pain perception in mice

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Lasers Surg. Med.; (United States)

DOI:https://doi.org/10.1002/lsm.1900090113· OSTI ID:5984948

Zarkovic, N; Manev, H; Pericic, D; Skala, K; Jurin, M; Persin, A; Kubovic, M

The influence of subacute exposure (11 exposures within 16 days) of mice to the low power (GaAs) semiconductive laser-stimulated irradiation on pain perception was investigated. The pain perception was determined by the latency of foot-licking or jumping from the surface of a 53 degrees C hot plate. Repeated hot-plate testing resulted in shortening of latencies in both sham- and laser-irradiated mice. Laser treatment (wavelength, 905 nm; frequency, 256 Hz; irradiation time, 50 sec; pulse duration, 100 nsec; distance, 3 cm; peak irradiance, 50 W/cm2 in irradiated area; and total exposure, 0.41 mJ/cm2) induced further shortening of latencies, suggesting its stimulatory influence on pain perception. Administration of morphine (20 mg/kg) prolonged the latency of response to the hot plate in both sham- and laser-irradiated mice. This prolongation tended to be lesser in laser-irradiated animals. Further investigations are required to elucidate the mechanism of the observed effect of laser.

• Research Organization: Ruder Boskovic Institute, Zagreb (Yugoslavia)
• OSTI ID: 5984948
• Journal Information: Lasers Surg. Med.; (United States), Vol. 9:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LASER RADIATION
BIOLOGICAL EFFECTS
PAIN
STIMULATION
ENDORPHINS
LASERS
MICE
MORPHINE
ALKALOIDS
ANALGESICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ELECTROMAGNETIC RADIATION
MAMMALS
NARCOTICS
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
RADIATIONS
RODENTS
SYMPTOMS
VERTEBRATES
560400* - Other Environmental Pollutant Effects