Genotoxicity of three-carbon compounds evaluated in the SCE test in vitro

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860090406· OSTI ID:5926645

von der Hude, W; Scheutwinkel, M; Gramlich, U; Fissler, B; Basler, A

Three-carbon chemicals (chlorinated and nonchlorinated, saturated and unsaturated, hydroxy- and oxo-hydrocarbons) were assay for genotoxicity. The sister chromatid exchange test in vitro served as the test system. Without S9 mix, the nonchlorinated solvents 1-propanol, 2-propanol, and 2-propanone (acetone) did not increase the SCE frequencies. All chlorinated 3-C hydrocarbons, except 1,2,3-trichloropropane, proved to be potent SCE inducers in V79 cells without S9 mix. In the presence of S9 mix, the results obtained with the nonchlorinated solvents were also negative, whereas, 1,2,3-trichloropropane was transformed to SCE-inducing metabolites. The addition of S9 mix resulted in an increased SCE rate for 2,3-dichloropropanol, whereas genotoxicity of 2,3-dichloropropene, 1,2-dichloropropane, 1,3-dichloropropene, and 1,3-dichloropropanone was reduced. 1,3-dichloropropanol, 1,3-dichloropropene, and epichlorohydrin were substantially inactivated by S9 mix in the V79/SCE test. It can be concluded the reactivity of the saturated dichloro compounds in the SCE test depends on the degree of oxidation. There is no general difference between the reactivity of ..cap alpha..,..beta..-dichloro and ..cap alpha..,omega-dichloro compounds.

• Research Organization: Max von Pettenkofer-Institute des Bundesgesundheitsamtes, Berlin, West Germany
• OSTI ID: 5926645
• Journal Information: Environ. Mutagen.; (United States), Vol. 9:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED ALIPHATIC HYDROCARBONS
GENETIC EFFECTS
PROPANOLS
ACETONE
FIBROBLASTS
HAMSTERS
IN VITRO
SISTER CHROMATID EXCHANGES
TOXICITY
ALCOHOLS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROXY COMPOUNDS
KETONES
MAMMALS
MUTATIONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RODENTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology