Dosimetry estimates for I-123-Orthoiodohippurate in children with normal and diseased kidneys

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5899500

Marcus, C S; Kuperus, J H

The radiation exposure to the kidney from I-123-OIH (Orthoiodohippurate) and any associated I-124-OIH contamination may vary by a factor of several hundred depending upon the health of the kidney. Dosimetry calculations were made for newborn, 1y, 5y, 10y, 15y, and 18y-old patients with the following renal states: normal, moderate ATN (Acute Tubular Necrosis), total obstruction with 5% and 50% uptake in each kidney, normal transplant, and transplant with moderate and severe ATN. The calculations were made for pure I-123 and I-123 with 10% contaminant I-124 at time of administration. The dosimetry was based on a minimum practical pediatric dose of 200..mu..Ci, a minimum practical adult dose of 500..mu..Ci, and a pediatric administered activity fraction calculated on the basis of the two-thirds power of body weight. High-grade obstruction of recent onset (i.e. high uptake) and severe ATN are the only disease processes which could result in high exposure doses. In the newborn, an obstructed kidney receives 16 rad (pure I-123) to 79 rad (+10% I-124 contaminant). It was noted that the presence of contaminant I-124 raises the exposures considerably. Care should be taken to ensure that excessive radiation exposures do not occur; in certain cases this means that OIH labeled with pure I-123 is strongly preferable to OIH labeled with I-123 containing I-124 contamination.

• Research Organization: Harbor-UCLA Medical Center, Torrance, CA
• OSTI ID: 5899500
• Report Number(s): CONF-850611-; TRN: 87-037530
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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CHILDREN
RADIATION DOSES
IODINE 123
BIOLOGICAL EFFECTS
DOSIMETRY
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
DISEASE INCIDENCE
AGE DEPENDENCE
AGE GROUPS
HIPPURAN
HIPPURIC ACID
IODINE 124
KIDNEYS
LABELLING
MONOCARBOXYLIC ACIDS
RADIOPHARMACEUTICALS
TRANSPLANTS
UPTAKE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
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