Renal graft irradiation in acute rejection

Journal Article · Tue Mar 01 00:00:00 EST 1983 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198303000-00004· OSTI ID:5854137

Pilepich, M V; Sicard, G A; Breaux, S R; Etheredge, E E; Blum, J; Anderson, C B

To evaluate the effect of graft irradiation in the treatment of acute rejection of renal transplants, a randomized study was conducted from 1978 to 1981. Patients with acute rejection were given standard medical management in the form of intravenous methylprednisolone, and were chosen randomly to receive either graft irradiation (175 rads every other day, to a total of 525 rads) or simulated (sham) irradiation. Eighty-three rejections occurring in 64 grafts were randomized to the protocol. Rejection reversal was recorded in 84.5% of control grafts and 75% of the irradiated grafts. Recurrent rejections were more frequent and graft survival was significantly lower in the irradiated group (22%) than in the control group (54%). Graft irradiation does not appear to be beneficial in the treatment of acute rejection of renal transplants when used in conjunction with high-dose steroids.

• Research Organization: Division of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri
• OSTI ID: 5854137
• Journal Information: Transplantation; (United States), Vol. 35:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GRAFT-HOST REACTION
RADIOTHERAPY
KIDNEYS
IRRADIATION
TRANSPLANTS
EVALUATION
PATIENTS
PREDNISOLONE
ADRENAL HORMONES
BODY
CORTICOSTEROIDS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PREGNANES
RADIOLOGY
STEROID HORMONES
STEROIDS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)