A randomized study of the efficacy of adjuvant local graft irradiation following renal transplantation

Journal Article · Tue May 01 04:00:00 EDT 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(90)90437-O· OSTI ID:7062201

Torrisi, J R; Dritschilo, A; Harter, K W; Helfrich, B; Berg, C D; Whitfield, G; Stablein, D; Alijani, M ^[1]

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1. Georgetown Univ. Hospital, Washington, DC (USA)

A prospective randomized study investigating the effectiveness of adjuvant local graft irradiation (LGI) following renal transplantation was performed at Georgetown University Hospital from 1983 until 1988. One hundred and thirty-eight patients were enrolled in the study with 117 patients receiving cadaver kidney transplantations and 21 patients receiving living related kidney transplantations. Seventy-one patients were randomized to receive adjuvant local graft irradiation consisting of 600 cGy in four fractions with chemical immunosuppression whereas the remaining 67 patients received chemical immunosuppression only (control group). The two groups were comparable at entry with respect to potentially important prognostic variables. Median follow-up for all patients was 30 months. The 3-year actuarial allograft success rate was 75% and 68% for the local graft irradiation and control groups, respectively. A nonsignificant trend favoring the irradiated group was noted. Subgroup analysis of the 21 recipients of kidneys from living related donors suggested an improvement in allograft survival for the local graft irradiation arm. Cadaver allograft survival was not significantly different between the two treatment arms. There was no apparent benefit in kidney function or time to the first rejection episode in the group receiving local graft irradiation.

• OSTI ID: 7062201
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (USA) Vol. 18:5; ISSN IOBPD; ISSN 0360-3016
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AZOLES
BODY
CREATININE
DOSES
DRUGS
FRACTIONATED IRRADIATION
GRAFT-HOST REACTION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
IMMUNITY
IMMUNOSUPPRESSION
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
KIDNEYS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION DOSES
RADIOINDUCTION
TRANSPLANTS