Vascular effects of free radicals generated by electrical stimulation
Electrical field stimulation (9 V, 1.0 ms, 4 Hz) of isolated segments of rat tail arteries and dog coronary arteries inhibits contractile response to exogenous norephinephrine and elevated potassium concentration. This inhibitory effect of electrical stimulation is blocked by various agents that alter oxygen metabolism: superoxide dismutase, catalase, glutathione, ascorbate, and dimethyl sulfoxide. The observations suggest that the inhibitory effect is due to an action of oxygen free radical metabolites that are generated by the electrical stimulation of the oxygen-rich buffer. These free radical metabolites have two actions: 1) they oxidize drugs in the experimental system, and 2) they exert a direct inhbitory action on vascular smooth muscle.
- Research Organization:
- Univ. of Michigan, Ann Arbor
- OSTI ID:
- 5742405
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 247:5
- Country of Publication:
- United States
- Language:
- English
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