Cerebral embolism: local CBF and edema measured by CT scanning and Xe inhalation
Serial CT scans were made in baboons after cerebral embolization during stable Xe inhalation for measuring local values for CBF and lambda (brain-blood partition or solubility coefficients), followed by iodine infusion for detecting blood-brain barrier (BBB) damage. Supplementary 133Xe CBF measurements were made at corresponding intervals. Persistent zones of zero flow surrounded by reduced flow were measured predominantly in subcortical regions, which showed gross and microscopic evidence of infarction at necropsy. Overylng cortex was relatively spared. Reduced lambda values attributed to edema appeared with in 3 to 5 minutes and progressed up to 60 minutes. Damage to BBB with visible transvascular seepage of iodine began to appear 1-11/2 hours after embolism. In chronic animals, lambda values were persistently reduced in areas showing histologic infarction. Contralateral hemispheric CBF increased for the first 15 minutes after embolism, followed by progressive reduction after 30 minutes (diaschisis).
- OSTI ID:
- 5728692
- Journal Information:
- Neurol. Res.; (United States), Vol. 2:2
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CARDIOVASCULAR SYSTEM
SCINTISCANNING
CEREBRUM
EDEMA
DIAGNOSIS
XENON 133
APES
BLOOD FLOW
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC USES
EMBOLI
PATHOLOGY
PERFUSED TISSUES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPTOMS
TISSUES
TOMOGRAPHY
USES
VERTEBRATES
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
550602 - Medicine- External Radiation in Diagnostics- (1980-)