Ultrastructural and pharmacologic studies on laser-induced glaucoma in primates and rabbits

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Lasers Surg. Med.; (United States)

DOI:https://doi.org/10.1002/lsm.1900040405· OSTI ID:5720057

March, W F; Gherezghiher, T; Koss, M; Nordquist, R

Sustained high intraocular pressure resulting in optic nerve cupping and loss of ganglion cells was produced in five rhesus monkeys and eight pigmented rabbits by applying argon laser energy to the trabecular meshwork. In addition, the rabbits manifested buphthalmus. Flow of carbon particles subsequently injected into the anterior chamber was obstructed at the trabecular meshwork by a wound-healing response that closed the intratrabecular spaces. Besides this sustained high intraocular pressure as a result of late scarring, an acute hypertensive response was seen in all rabbits which may correspond to the acute hypertension seen after laser trabeculoplasty in humans. The acute hypertensive response could be only partially blocked by prostaglandin inhibitors and the authors believe that prostaglandins are not primarily responsible for this effect. Medications known to lower intraocular pressure were systematically tested in both glaucoma models.

• Research Organization: Univ. of Oklahoma, Oklahoma City
• OSTI ID: 5720057
• Journal Information: Lasers Surg. Med.; (United States), Vol. 4:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LASERS
BIOLOGICAL EFFECTS
MONKEYS
SENSE ORGANS DISEASES
RABBITS
BIOLOGICAL MODELS
HEALING
HYPERTENSION
LASER RADIATION
NERVES
PROSTAGLANDINS
WOUNDS
ANIMALS
BIOLOGICAL RECOVERY
CARDIOVASCULAR DISEASES
DISEASES
ELECTROMAGNETIC RADIATION
INJURIES
MAMMALS
NERVOUS SYSTEM
PRIMATES
RADIATIONS
RECOVERY
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560400* - Other Environmental Pollutant Effects