Involvement of histamine H1 and H2 receptors in hypothermia induced by ionizing radiation in guinea pigs
Radiation-induced hypothermia was examined in guinea pigs. Exposure to the head alone or whole-body irradiation induced hypothermia, whereas exposure of the body alone produced a small insignificant response. Systemic injection of disodium cromoglycate (a mast cell stabilizer) and cimetidine (H2-receptor antagonist) had no effect on radiation-induced hypothermia, whereas systemic and central administration of mepyramine (H1-receptor antagonist) or central administration of disodium cromoglycate or cimetidine attenuated it, indicating the involvement of central histamine through both H1 and H2 receptors in this response. Serotonin is not involved, since the serotonin antagonist methysergide had no effect on radiation-induced hypothermia. These results indicate that central histaminergic systems may be involved in radiation-induced hypothermia. 34 references, 5 figures, 2 tables.
- Research Organization:
- Armed Forces Radiobiology Research Institute, Bethesda, MD
- OSTI ID:
- 5650210
- Journal Information:
- Life Sci.; (United States), Vol. 42:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HISTAMINE
BIOLOGICAL FUNCTIONS
RECEPTORS
HYPOTHERMIA
RADIOINDUCTION
BIOLOGICAL RADIATION EFFECTS
EXPERIMENTAL DATA
GUINEA PIGS
IONIZING RADIATIONS
PARTIAL BODY IRRADIATION
RESPONSE MODIFYING FACTORS
WHOLE-BODY IRRADIATION
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BODY TEMPERATURE
DATA
EXTERNAL IRRADIATION
FUNCTIONS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INFORMATION
IRRADIATION
MAMMALS
MEMBRANE PROTEINS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals