Involvement of histamine H1 and H2 receptors in hypothermia induced by ionizing radiation in guinea pigs

Technical Report · Thu Dec 31 23:00:00 EST 1987

OSTI ID:6994434

Kandasamy, S B; Hunt, W A

Radiation-induced hypothermia was examined in guinea pigs. Exposure to the head alone or whole-body irradiation-induced hypothermia, whereas exposure of the body alone produced a small insignificant response. Systemic injection of disodium cromoglycate (a mast cell stabilizer) and cimetidine (H2-receptor antagonist) had no effect on radiation-induced hypothermia, whereas systemic and central administration of mepyramine (H1-receptor antagonist) or central administration disodium cromoglycate or cimetidine attenuated it, indicating the involvement of central histamine through both H1 and H2 receptors in this response. Serotonin is not involved, since the serotonin antagonist methysergide had no effect on radiation-induced hypothermia. These results indicate that central histaminergic systems may be involved in radiation-induced hypothermia.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 6994434
• Report Number(s): AD-A-192774/8/XAB; AFRRI-SR-87-38
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CONNECTIVE TISSUE CELLS
DRUGS
EFFICIENCY
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
HYDROXY COMPOUNDS
HYPOTHERMIA
IMIDAZOLES
INDOLES
INJECTION
INTAKE
MAMMALS
MAST CELLS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRROLES
RADIATION EFFECTS
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RODENTS
SEROTONIN
SOMATIC CELLS
SYMPATHOMIMETICS
TRYPTAMINES
VERTEBRATES